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Toxoplasmic Encephalitis in Patients with the Acquired Immunodeficiency Syndrome NEJM 329:995-1000, Luft,B.J.,et al, 1993 See this aricle in Pubmed Article Abstract Thirty-five of 49 patients(71 percent)responded to therapy,and 30 of these (86 percent)had improvement by day 7.Thirty-two of those those with a response(91 percent)improved with respect to at least half of their base- line abnormalities by day 14.Improvement in neurologic abnormalities within 7 to 14 days after the start of therapy was strongly associated with the neurologic response at 6 weeks.The four patients in whom treatment failed and the two patients with lymphoma had progressing neurologic abnormalities or new abnormalities during the first 12 days of therapy.Nonlocalizing abnormalities(headache and seizure)improved regardless of the clinical outcome.Oral clindamycin and pyrimethamine are an effective treatment for toxoplasmic encephalitis.Patients who have early neurologic deteriorating despite treatment or who do not improve neurologically after 10 to 14 days of appropriate antitoxoplasma therapy should be considered candidates for brain biopsy.

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(click to filter results - removes previous filter) acquired immunodeficiency syndrome brain biopsy CD4 counts clindamycin meningoencephalitis,toxoplasma opportunistic infection opportunistic infection,CNS pyrimethamine toxoplasmosis,acquired toxoplasmosis,CNS treatment of neurologic disorder

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